Neurologists on the Front Line: Infected Patients and the Role of the Brain in Neurodegenerative Diseases in the US
The patients included in this study were under 18 years of age and had a history of neurodegenerative diseases such as Alzheimer's, Parkinson's, and multisystem inflammatory syndrome, as well as multiple sclerosis.
Reported neurological manifestations included, but were not limited to, necrotizing encephalopathy, demyelinated headache, and may or may not include cerebral edema, seizures, cramps, dizziness, nausea, vomiting, diarrhea, and vomiting. In the severe group, 1% of the patients had seizures characterized by severe seizures with central nervous system seizures lasting up to 3 minutes and foaming at the mouth.
Neurological symptoms that occurred during the infection process also include headaches, racing heart, tremors, muscle spasms, headaches, fever, headaches, and nausea. The less common neurodegenerative complications were disseminated encephalitis, hypotension, spasticity, weakness, numbness, loss of coordination, confusion, memory loss, and seizures.
The severity of neurological symptoms ranged from mild to severe, with the most common and common symptoms being headaches, dizziness, nausea, vomiting, fever, diarrhea, and vomiting. The neurological manifestations of the viral infections reported so far can be further divided into CNS and peripheral nervous system (PNS) features. Some of the more common CNS symptoms that have been reported have resulted in more severe symptomatic manifestations in the CNS, which may include anemia, meningitis, and bleeding.
While mild encephalitis causes a temporary flu - such as headaches, dizziness, nausea, vomiting, fever, diarrhea and vomiting, and anemia - more severe cases cause severe neurological symptoms, such as loss of hearing when speaking and increased of deaths, with milder symptoms such as headaches and nausea.
If SARS-CoV-2 is responsible for these symptoms, the second important question to answer is whether these neurological features are due to direct damage to the nervous system or to the effects of the viral infection itself.
People with neurological disorders are more likely to suffer from the most serious complications of infectious diseases. Rather, the infection itself can be the source of neurological complications. Given the high incidence of SARS-CoV-2 infections in the US and other countries, it is likely that there is an incidental incidence of these neurological diseases.
The body's immune system is more likely to continue firing after the virus is released"says Dr. Mukerji, who has studied the neurological complications of Covid-19. Although this publication does not focus on neurological symptoms, there is evidence of specific neurological effects that may indicate direct neuropathology. More data will help strengthen the link between coronavirus - related brain infections and associated neurological symptoms - says Dr. Mukherji.
The study, which is considered the first comprehensive examination of the neurological consequences of SARS-CoV-2 infections, includes several clinical and experimental studies in humans and examines the clinical and epidemiological evidence of neurological disorders associated with brain infection by coronavirus. It represents a significant advance in the understanding of neurological diseases and their possible role in infectious diseases.
Neurological manifestations can be divided into three categories: central, peripheral, temporal, and peripheral neuropathology. The neurological implication of COVID-19 is discussed in detail in the article "Neurological Consequences of SARS - CoV-2 Infection with Coronavirus". First of all, we must report on the neurological symptoms caused by COVID-19 and the neuropathic symptoms of the disease in humans.
In May 2020, Reichard and his colleagues described several types of pathological lesions that can contribute to the neurological manifestations seen in COVID-19 patients. Although most of the neurological symptoms of covid occur in the early stages of the disease, these manifestations can be verified and confirmed by trained neurologists. More studies are urgently needed to distinguish the disease - the associated viral presence of COVID-19 and to describe the brain damage caused by SARS-CoV-2.
Mao and others  reported seizures and hemiplegia in patients with SARS-CoV-2 infection in the early days of illness. At months 15, 21, and 27, there was a slow recovery, but no significant improvement in symptoms of cerebral palsy, seizures, or other neurological symptoms of COVID in 14-30 days.
Helms et al. Reported that of 68 patients admitted in the early days of illness due to acute respiratory distress from SARS-CoV-2 infection, 58 had neurological abnormalities. Of these, 78 patients had neurological abnormalities, 25 had problems related to skeletal muscle injuries, 11 had symptoms related to CNS dysfunction, 9 had symptoms of cerebral palsy, seizures, or other neurological symptoms within 14 to 30 days, and two they had suffered an acute ischemic stroke.
Strokes were also reported in patients with Sars-CoV-2 infection, based on the results of a clinical trial with a group of US patients Of 68 consecutive patients, 68 of whom had an ischemic stroke Subacute, two seizures and hemiplegia immediately after admission, 10 had neurological dysfunction and 25 symptoms related to CNS dysfunction.
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